![]() 6, 7 These products are then recognized and excised by thymine DNA glycosylase Oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC)Īnd eventually to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Translocation (Tet) proteins, which were shown to be capable of the Of DNA methylation were greatly abetted by the discovery of the ten–eleven 5 Investigations into the mechanisms and dynamics ![]() The principal modification is at the 5′ position of cytosineĪnd is installed via S-adenosylmethionine (SAM) 4 by various DNA methyltransferases (DNMTs). Importance has been well established in developmental processes, 1 and aberrant patterns have been linked to various Been known as a repressive epigenetic mode of gene regulation.
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